Human saphenous vein organ culture under controlled hemodynamic conditions
نویسندگان
چکیده
منابع مشابه
Human Saphenous Vein Organ Culture Under Controlled Hemodynamic Conditions
INTRODUCTION Saphenous vein grafting is still widely used to revascularize ischemic myocardium. The effectiveness of this procedure is limited by neointima formation and accelerated atherosclerosis, which frequently leads to graft occlusion. A better understanding of this process is important to clarify the mechanisms of vein graft disease and to aid in the formulation of strategies for prevent...
متن کاملAction of angiotensin II on DNA synthesis by human saphenous vein in organ culture.
Angiotensin II (Ang II), an effector peptide of the renin-angiotensin system, has been reported to stimulate growth of blood vessels in vivo and smooth muscle cells in culture. In this study, the effect of Ang II on DNA synthesis was examined in deendothelialized human saphenous vein in organ culture. After 7 days' exposure to medium containing 0.4% fetal calf serum plus Ang II, there was a mar...
متن کاملPulsatile ex vivo perfusion of human saphenous vein grafts under controlled pressure conditions increases MMP-2 expression
BACKGROUND The use of human saphenous vein grafts (HSVGs) as a bypass conduit is a standard procedure in the treatment of coronary artery disease while their early occlusion remains a major problem. METHODS We have developed an ex vivo perfusion system, which uses standardized and strictly controlled hemodynamic parameters for the pulsatile and non-static perfusion of HSVGs to guarantee a rel...
متن کاملHuman Saphenous Vein
We performed experiments to determine whether or not acetylcholine exerts a prejunctional inhibitory effect on adrenergic neurotransmission in the human blood vessel wall. Rings of human greater saphenous veins were prepared 2 to 15 hours after death and mounted for isometric tension recording in organ chambers filled with Krebs-Ringer solution. Acetylcholine depressed contractile responses to ...
متن کاملOpening angle of human saphenous vein
In this study, the residual strain was evaluated for human saphenous vein. Rings of the vein from four donors (two male and two female; age 62±5 years) were radially cut to obtain the opening angle (α) of the tissue. It was found that the average opening angle is 45°±18° (mean±SD). Then, the intraluminal distribution of circumferential stress was computed for one donor in order to verify the un...
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ژورنال
عنوان ژورنال: Clinics
سال: 2008
ISSN: 1807-5932
DOI: 10.1590/s1807-59322008000500018